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KMID : 0921620200500020107
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Journal of Bacteriology and Virology
2020 Volume.50 No. 2 p.107 ~ p.116
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Prevalence of Carbapenem-Resistant Enterobacteriaceae in Seoul, Korea
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Park Sang-Hun
Kim Jin-Seok
Kim Hee-Soon
Yu Jin-Kyung
Han Sung-Hee
Kang Min-Ji
Hong Chae-Kyu
Lee Sang-Me
Oh Young-Hee
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Abstract
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The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is increasing globally. However, a few studies have addressed their epidemiology in Seoul, Korea. In this study, we conducted one-year surveillance of CRE among 1,468 clinical isolates of Enterobacteriaceae at the hospital in Seoul with molecular characterization of carbapenemase genes. About 85% of CRE-positive samples were isolated from the elderly age group (above 60 years). The most common isolated organisms were Klebsiella pneumoniae (K. pneumoniae) (56.5%) and Escherichia coli (E.coli) (17.0%). We detected six different Carbapenemase-producing Enterobacteriaceae (CPE) of bla KPC , bla NDM , bla OXA , bla VIM , bla IMP , and bla GES alone or in combination with other bla genes. Typically, 853 (58.1%) isolates were tested positive for at least one CPE. KPC (K. pneumoniae carbapenemase)-2 was the most common CPE type (46.0%) followed by NDM (New Delhi metallo-β-lactamase)-1 (5.9%). KPC-2 was most commonly found in K. pneumoniae (494/676 isolates [73.1%]) and E.coli (107/676 isolates [15.8%]), whereas NDM-1 was commonly found in Enterobacter cloacae complex (20/86 isolates [23.3%]). Detailed information and molecular characteristics of CPE is essential to prevent the spread of these pathogens.
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KEYWORD
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Carbapenem-resistant Enterobacteriaceae (CRE), Carbapenemase-producing Enterobacteriaceae (CPE), Klebsiella pneumoniae
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